Interactions médicamenteuses
Ascorbic acid + Deferoxamine
Gravité: Majeure
Ascorbic acid and Deferoxamine: major interaction.
Dernière mise à jour
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Résumé
Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
Ce que signifie cette interaction, en termes simples
Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Ascorbic acid increases the pool of chelatable iron, and the redox-active iron released may cause cardiac toxicity.
Conduite à tenir
Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Deferoxamine
Questions fréquentes
Can I take Ascorbic acid with Deferoxamine?
MediHelp rates the interaction as major. Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
How serious is the interaction between Ascorbic acid and Deferoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
What other medicines interact with Deferoxamine?
MediHelp also lists interactions of Deferoxamine with, for example, Betibeglogene autotemcel, Exagamglogene autotemcel, Lovotibeglogene autotemcel. The full list is on the Deferoxamine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
