Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Atazanavir + Eplerenone

Gravité: Contre-indiquée

Atazanavir and Eplerenone: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Atazanavir is a strong CYP3A4 inhibitor, and eplerenone is a sensitive CYP3A4 substrate. Eplerenone exposure can rise markedly, increasing the risk of hyperkalemia. Labeling contraindicates eplerenone with strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Atazanavir and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Atazanavir belongs to Anti Virals; Eplerenone belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Strong CYP3A4 inhibition by atazanavir reducing eplerenone metabolism.

Conduite à tenir

Do not combine; choose a different antiretroviral or a different mineralocorticoid antagonist such as spironolactone with potassium monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Atazanavir et Eplerenone, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Atazanavir with Eplerenone?

MediHelp rates the interaction as contraindicated. Atazanavir and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir is a strong CYP3A4 inhibitor, and eplerenone is a sensitive CYP3A4 substrate. Eplerenone exposure can rise markedly, increasing the risk of hyperkalemia. Labeling contraindicates eplerenone with strong CYP3A4 inhibitors.

How serious is the interaction between Atazanavir and Eplerenone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a different antiretroviral or a different mineralocorticoid antagonist such as spironolactone with potassium monitoring.

What other medicines interact with Eplerenone?

MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Clarithromycin, Cobicistat. The full list is on the Eplerenone page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter