Interactions médicamenteuses
Atenolol-chlorthalidone + Carbenoxolone
Gravité: Majeure
Atenolol-chlorthalidone and Carbenoxolone: major interaction.
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Résumé
Carbenoxolone causes mineralocorticoid-like sodium and water retention and potassium loss, which can raise blood pressure and oppose the antihypertensive effect. Combined with chlorthalidone, the risk of hypokalemia is considerably increased.
Ce que signifie cette interaction, en termes simples
Atenolol-chlorthalidone and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that adds to thiazide-induced potassium wasting and counteracts antihypertensive therapy.
Conduite à tenir
Avoid the combination where possible; if used, monitor serum potassium and blood pressure regularly and correct hypokalemia promptly.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Atenolol-chlorthalidone
Questions fréquentes
Can I take Atenolol-chlorthalidone with Carbenoxolone?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone causes mineralocorticoid-like sodium and water retention and potassium loss, which can raise blood pressure and oppose the antihypertensive effect. Combined with chlorthalidone, the risk of hypokalemia is considerably increased.
How serious is the interaction between Atenolol-chlorthalidone and Carbenoxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and blood pressure regularly and correct hypokalemia promptly.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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