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Interactions médicamenteuses

Atorvastatin + Vitamin b3

Gravité: Modérée

Atorvastatin and Vitamin b3: moderate interaction.

Dernière mise à jour

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Résumé

Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.

Ce que signifie cette interaction, en termes simples

Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atorvastatin belongs to Cardiovascular; Vitamin b3 belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myotoxicity, with a possible minor pharmacokinetic contribution; the mechanism is not fully established.

Conduite à tenir

Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atorvastatin with Vitamin b3?

MediHelp rates the interaction as moderate. Atorvastatin and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lipid-lowering doses of niacin combined with a statin may increase the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at higher niacin doses and in patients with renal impairment or older age.

How serious is the interaction between Atorvastatin and Vitamin b3?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report unexplained muscle pain or weakness. Check CK if symptoms occur and stop therapy if myopathy is suspected.

What other medicines interact with Vitamin b3?

MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Cholestyramine. The full list is on the Vitamin b3 page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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