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Interactions médicamenteuses

Azilsartan + Captopril

Gravité: Majeure

Azilsartan and Captopril: major interaction.

Dernière mise à jour

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Résumé

Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without proven outcome benefit.

Ce que signifie cette interaction, en termes simples

Azilsartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azilsartan belongs to Cardiovascular; Captopril belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive blockade of the renin-angiotensin-aldosterone system at two levels.

Conduite à tenir

Avoid the combination, particularly in diabetic nephropathy. If used, monitor potassium, creatinine and blood pressure closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azilsartan with Captopril?

MediHelp rates the interaction as major. Azilsartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and acute kidney injury without proven outcome benefit.

How serious is the interaction between Azilsartan and Captopril?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, particularly in diabetic nephropathy. If used, monitor potassium, creatinine and blood pressure closely.

What other medicines interact with Captopril?

MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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