Interactions médicamenteuses
Benzhydrocodone / acetaminophen + Isoniazid
Gravité: Majeure
Benzhydrocodone / acetaminophen and Isoniazid: major interaction.
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Résumé
Isoniazid inhibits CYP3A4, which clears hydrocodone, so opioid exposure can increase and risk respiratory depression and sedation. Isoniazid and acetaminophen both carry hepatotoxic potential, with isoniazid possibly increasing toxic acetaminophen metabolite formation.
Ce que signifie cette interaction, en termes simples
Benzhydrocodone / acetaminophen and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
CYP3A4 inhibition raises hydrocodone levels, and isoniazid-related CYP2E1 effects plus additive hepatotoxicity apply to acetaminophen.
Conduite à tenir
Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Monitor liver function and limit acetaminophen total daily dose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Isoniazid
- Bacillus calmette-guerin substrain tice + Isoniazid Majeure
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- Dihydroergotamine + Isoniazid Majeure
- Ergotamine + Isoniazid Majeure
Questions fréquentes
Can I take Benzhydrocodone / acetaminophen with Isoniazid?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoniazid inhibits CYP3A4, which clears hydrocodone, so opioid exposure can increase and risk respiratory depression and sedation. Isoniazid and acetaminophen both carry hepatotoxic potential, with isoniazid possibly increasing toxic acetaminophen metabolite formation.
How serious is the interaction between Benzhydrocodone / acetaminophen and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Monitor liver function and limit acetaminophen total daily dose.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Carbamazepine, Didanosine. The full list is on the Isoniazid page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
