Interactions médicamenteuses
Buprenorphine long-acting + Ethosuximide
Gravité: Majeure
Buprenorphine long-acting and Ethosuximide: major interaction.
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Résumé
Concurrent use of long-acting injectable buprenorphine with a CNS depressant such as ethosuximide increases the risk of sedation and respiratory depression. The depot effect means the opioid cannot be quickly withdrawn if problems occur.
Ce que signifie cette interaction, en termes simples
Buprenorphine long-acting and Ethosuximide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression.
Conduite à tenir
Monitor for oversedation and respiratory depression, particularly after injection and with ethosuximide dose changes. Avoid additional sedatives and alcohol.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Majeure
- Buprenorphine subdermal implant + Ethosuximide Majeure
- Buprenorphine transdermal + Ethosuximide Majeure
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Majeure
- Ethosuximide + Fentanyl intranasal Majeure
- Ethosuximide + Fentanyl iontophoretic transdermal system Majeure
Questions fréquentes
Can I take Buprenorphine long-acting with Ethosuximide?
MediHelp rates the interaction as major. Buprenorphine long-acting and Ethosuximide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of long-acting injectable buprenorphine with a CNS depressant such as ethosuximide increases the risk of sedation and respiratory depression. The depot effect means the opioid cannot be quickly withdrawn if problems occur.
How serious is the interaction between Buprenorphine long-acting and Ethosuximide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression, particularly after injection and with ethosuximide dose changes. Avoid additional sedatives and alcohol.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine subdermal implant, Buprenorphine transdermal. The full list is on the Ethosuximide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
