Interactions médicamenteuses
Butabarbital + Etonogestrel
Gravité: Majeure
Butabarbital and Etonogestrel: major interaction.
Dernière mise à jour
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Résumé
Barbiturates are enzyme inducers that accelerate progestin metabolism and can lower etonogestrel concentrations enough to cause contraceptive failure. Unintended pregnancy has been reported with enzyme-inducing drugs and implants.
Ce que signifie cette interaction, en termes simples
Butabarbital and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Induction of hepatic CYP3A4 by butabarbital increases etonogestrel clearance.
Conduite à tenir
Use an alternative non-hormonal or non-induced-sensitive method such as a copper IUD or DMPA, or add condoms during and for several weeks after barbiturate use.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Etonogestrel
- Amobarbital + Etonogestrel Majeure
- Armodafinil + Etonogestrel Majeure
- Bosentan + Etonogestrel Majeure
- Brigatinib + Etonogestrel Majeure
- Carbamazepine + Etonogestrel Majeure
- Efavirenz + Etonogestrel Majeure
Questions fréquentes
Can I take Butabarbital with Etonogestrel?
MediHelp rates the interaction as major. Butabarbital and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates are enzyme inducers that accelerate progestin metabolism and can lower etonogestrel concentrations enough to cause contraceptive failure. Unintended pregnancy has been reported with enzyme-inducing drugs and implants.
How serious is the interaction between Butabarbital and Etonogestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative non-hormonal or non-induced-sensitive method such as a copper IUD or DMPA, or add condoms during and for several weeks after barbiturate use.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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