Interactions médicamenteuses
Calcium carbonate + Delafloxacin
Gravité: Modérée
Calcium carbonate and Delafloxacin: moderate interaction.
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Résumé
Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
Ce que signifie cette interaction, en termes simples
Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Delafloxacin belongs to Anti Bacterial.
Pourquoi elle survient
Chelation of delafloxacin by calcium cations in the gastrointestinal tract reduces its oral absorption.
Conduite à tenir
Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Calcium carbonate
Autres interactions de Delafloxacin
- Aluminum hydroxide + Delafloxacin Modérée
- Calcium + Delafloxacin Modérée
- Carbonyl iron + Delafloxacin Modérée
- Delafloxacin + Didanosine Modérée
- Delafloxacin + Ferrous fumarate Modérée
- Delafloxacin + Ferrous gluconate Modérée
Questions fréquentes
Can I take Calcium carbonate with Delafloxacin?
MediHelp rates the interaction as moderate. Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
How serious is the interaction between Calcium carbonate and Delafloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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