Interactions médicamenteuses
Calcium / magnesium / potassium / sodium oxybates + Dantrolene
Gravité: Majeure
Calcium / magnesium / potassium / sodium oxybates and Dantrolene: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Oxybates are potent CNS depressants that can cause respiratory depression, and dantrolene adds sedation and muscle weakness. Together they may cause profound sedation, respiratory depression, coma or death.
Ce que signifie cette interaction, en termes simples
Calcium / magnesium / potassium / sodium oxybates and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive central nervous system depression from oxybate with dantrolene's sedative and muscle-weakening effects.
Conduite à tenir
Avoid the combination where possible; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression. Consider an alternative muscle relaxant or dose reduction of either drug.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Dantrolene
Questions fréquentes
Can I take Calcium / magnesium / potassium / sodium oxybates with Dantrolene?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates are potent CNS depressants that can cause respiratory depression, and dantrolene adds sedation and muscle weakness. Together they may cause profound sedation, respiratory depression, coma or death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression. Consider an alternative muscle relaxant or dose reduction of either drug.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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