Interactions médicamenteuses
Cefalexin + Kanamycin
Gravité: Modérée
Cefalexin and Kanamycin: moderate interaction.
Dernière mise à jour
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Résumé
Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
Ce que signifie cette interaction, en termes simples
Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive nephrotoxic potential, with reduced renal function leading to higher aminoglycoside accumulation and ototoxicity risk.
Conduite à tenir
Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefalexin
- Amikacin + Cefalexin Modérée
- Avelumab + Cefalexin Modérée
- Balstilimab + Cefalexin Modérée
- Bcg vaccine live + Cefalexin Modérée
- Cefalexin + Cholera vaccine Modérée
- Cefalexin + Gentamicin Modérée
Questions fréquentes
Can I take Cefalexin with Kanamycin?
MediHelp rates the interaction as moderate. Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
How serious is the interaction between Cefalexin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
