Interactions médicamenteuses
Cefotetan + Warfarin
Gravité: Majeure
Cefotetan and Warfarin: major interaction.
Dernière mise à jour
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Résumé
Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
Ce que signifie cette interaction, en termes simples
Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cefotetan belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Pourquoi elle survient
Its N-methylthiotetrazole side chain inhibits vitamin K epoxide reductase and gut flora reduce vitamin K availability, adding to warfarin effect.
Conduite à tenir
Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Warfarin
- Defibrotide + Warfarin Contre-indiquée
- Ketorolac + Warfarin Contre-indiquée
- Abciximab + Warfarin Majeure
- Acetylsalicylic acid + Warfarin Majeure
- Adagrasib + Warfarin Majeure
- Amiodarone + Warfarin Majeure
Autres interactions de Cefotetan
- Cefotetan + Dronabinol Contre-indiquée
- Amikacin + Cefotetan Modérée
- Argatroban + Cefotetan Modérée
- Cefotetan + Dalteparin Modérée
- Cefotetan + Enoxaparin Modérée
- Cefotetan + Fondaparinux Modérée
Questions fréquentes
Can I take Cefotetan with Warfarin?
MediHelp rates the interaction as major. Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
How serious is the interaction between Cefotetan and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
