Interactions médicamenteuses
Cefoxitin + Chloramphenicol
Gravité: Modérée
Cefoxitin and Chloramphenicol: moderate interaction.
Dernière mise à jour
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Résumé
Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
Ce que signifie cette interaction, en termes simples
Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Pourquoi elle survient
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis by chloramphenicol may blunt the growth-dependent killing by beta-lactams.
Conduite à tenir
Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefoxitin
- Amikacin + Cefoxitin Modérée
- Aztreonam + Cefoxitin Modérée
- Bcg vaccine live + Cefoxitin Modérée
- Cefoxitin + Cholera vaccine Modérée
- Cefoxitin + Dexamethasone-tobramycin Modérée
- Cefoxitin + Gentamicin Modérée
Autres interactions de Chloramphenicol
Questions fréquentes
Can I take Cefoxitin with Chloramphenicol?
MediHelp rates the interaction as moderate. Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
How serious is the interaction between Cefoxitin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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