Interactions médicamenteuses
Chloramphenicol + Vitamin B12
Gravité: Modérée
Chloramphenicol and Vitamin B12: moderate interaction.
Dernière mise à jour
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Résumé
Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
Ce que signifie cette interaction, en termes simples
Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vitamin B12 belongs to Gastrointestinal Tract.
Pourquoi elle survient
Chloramphenicol-induced bone marrow suppression counteracts the erythropoietic response to B12 replacement.
Conduite à tenir
Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Vitamin B12
Autres interactions de Chloramphenicol
Questions fréquentes
Can I take Chloramphenicol with Vitamin B12?
MediHelp rates the interaction as moderate. Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
How serious is the interaction between Chloramphenicol and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Dichlorphenamide, Metformin, Neomycin po. The full list is on the Vitamin B12 page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
