Interactions médicamenteuses
Clemastine + Dextromoramide
Gravité: Majeure
Clemastine and Dextromoramide: major interaction.
Dernière mise à jour
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Résumé
Dextromoramide is a potent opioid, and a sedating antihistamine can substantially add to sedation and psychomotor impairment. Respiratory depression is a risk, especially at higher opioid doses.
Ce que signifie cette interaction, en termes simples
Clemastine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from the opioid agonist and the sedating H1 antihistamine.
Conduite à tenir
Use the lowest effective doses and monitor for sedation and respiratory depression. Prefer a non-sedating antihistamine and advise avoiding alcohol and driving.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Clemastine
Questions fréquentes
Can I take Clemastine with Dextromoramide?
MediHelp rates the interaction as major. Clemastine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and a sedating antihistamine can substantially add to sedation and psychomotor impairment. Respiratory depression is a risk, especially at higher opioid doses.
How serious is the interaction between Clemastine and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Prefer a non-sedating antihistamine and advise avoiding alcohol and driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
