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Interactions médicamenteuses

Dasatinib + Rabeprazole

Gravité: Majeure

Dasatinib and Rabeprazole: major interaction.

Dernière mise à jour

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Résumé

Dasatinib dissolves best in acid, and rabeprazole suppresses gastric acid for many hours. Dasatinib exposure may fall significantly, risking reduced response in leukemia treatment.

Ce que signifie cette interaction, en termes simples

Dasatinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dasatinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

Higher gastric pH reduces the pH-dependent solubility and absorption of dasatinib.

Conduite à tenir

Avoid PPIs with dasatinib. If acid suppression is needed, use an antacid taken at least 2 hours before or after dasatinib, or consider a short-acting H2 blocker given 2 hours before dasatinib.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dasatinib with Rabeprazole?

MediHelp rates the interaction as major. Dasatinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib dissolves best in acid, and rabeprazole suppresses gastric acid for many hours. Dasatinib exposure may fall significantly, risking reduced response in leukemia treatment.

How serious is the interaction between Dasatinib and Rabeprazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. If acid suppression is needed, use an antacid taken at least 2 hours before or after dasatinib, or consider a short-acting H2 blocker given 2 hours before dasatinib.

What other medicines interact with Rabeprazole?

MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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