Interactions médicamenteuses
Diatrizoate + Metformin
Gravité: Majeure
Diatrizoate and Metformin: major interaction.
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Résumé
Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
Ce que signifie cette interaction, en termes simples
Diatrizoate and Metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation.
Conduite à tenir
In patients with eGFR below 30, or with acute kidney injury or intra-arterial contrast, withhold metformin at the time of the procedure and for 48 hours afterward. Restart only after renal function has been re-evaluated and found stable.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Metformin
- Contrast media + Metformin Majeure
- Diatrizoate meglumine / diatrizoate + Metformin Majeure
- Ethanol + Metformin Majeure
- Iodixanol + Metformin Majeure
- Iohexol + Metformin Majeure
- Iopamidol + Metformin Majeure
Questions fréquentes
Can I take Diatrizoate with Metformin?
MediHelp rates the interaction as major. Diatrizoate and Metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
How serious is the interaction between Diatrizoate and Metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with eGFR below 30, or with acute kidney injury or intra-arterial contrast, withhold metformin at the time of the procedure and for 48 hours afterward. Restart only after renal function has been re-evaluated and found stable.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Ethanol. The full list is on the Metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
