Interactions médicamenteuses
Diatrizoate meglumine / diatrizoate + Glipizide-metformin
Gravité: Majeure
Diatrizoate meglumine / diatrizoate and Glipizide-metformin: major interaction.
Dernière mise à jour
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Résumé
Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
Ce que signifie cette interaction, en termes simples
Diatrizoate meglumine / diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Contrast-associated acute kidney injury reduces renal elimination of metformin, leading to accumulation and lactic acidosis.
Conduite à tenir
Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glipizide-metformin
Questions fréquentes
Can I take Diatrizoate meglumine / diatrizoate with Glipizide-metformin?
MediHelp rates the interaction as major. Diatrizoate meglumine / diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
How serious is the interaction between Diatrizoate meglumine / diatrizoate and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate, Diazoxide. The full list is on the Glipizide-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
