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Interactions médicamenteuses

Disopyramide + Sotalol

Gravité: Contre-indiquée

Disopyramide and Sotalol: contraindicated interaction.

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Résumé

Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.

Ce que signifie cette interaction, en termes simples

Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Disopyramide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation and additive negative inotropic effect.

Conduite à tenir

Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Disopyramide with Sotalol?

MediHelp rates the interaction as contraindicated. Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.

How serious is the interaction between Disopyramide and Sotalol?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.

What other medicines interact with Sotalol?

MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Dofetilide. The full list is on the Sotalol page.

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