Interactions médicamenteuses
Duvelisib + Regorafenib
Gravité: Majeure
Duvelisib and Regorafenib: major interaction.
Dernière mise à jour
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Résumé
Duvelisib inhibits CYP3A4 and may raise regorafenib exposure, increasing hepatotoxicity, hypertension and hand-foot skin reaction. Regorafenib may in turn increase duvelisib exposure through BCRP inhibition, adding to duvelisib toxicities such as infections, diarrhea and skin reactions.
Ce que signifie cette interaction, en termes simples
Duvelisib and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Regorafenib belongs to Oncology.
Pourquoi elle survient
Duvelisib inhibits CYP3A4 metabolism of regorafenib, and regorafenib inhibits BCRP-mediated efflux of duvelisib.
Conduite à tenir
Consider avoiding the combination or reducing the regorafenib dose, with close monitoring of liver function, blood pressure and skin toxicity. Monitor for duvelisib toxicities including infection and severe diarrhea.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Regorafenib
- Apalutamide + Regorafenib Majeure
- Atazanavir + Regorafenib Majeure
- Carbamazepine + Regorafenib Majeure
- Clarithromycin + Regorafenib Majeure
- Conivaptan + Regorafenib Majeure
- Dabrafenib + Regorafenib Majeure
Autres interactions de Duvelisib
- Duvelisib + Ergotamine Contre-indiquée
- Alfuzosin + Duvelisib Majeure
- Apalutamide + Duvelisib Majeure
- Avanafil + Duvelisib Majeure
- Carbamazepine + Duvelisib Majeure
- Chloramphenicol + Duvelisib Majeure
Questions fréquentes
Can I take Duvelisib with Regorafenib?
MediHelp rates the interaction as major. Duvelisib and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and may raise regorafenib exposure, increasing hepatotoxicity, hypertension and hand-foot skin reaction. Regorafenib may in turn increase duvelisib exposure through BCRP inhibition, adding to duvelisib toxicities such as infections, diarrhea and skin reactions.
How serious is the interaction between Duvelisib and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider avoiding the combination or reducing the regorafenib dose, with close monitoring of liver function, blood pressure and skin toxicity. Monitor for duvelisib toxicities including infection and severe diarrhea.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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