Interactions médicamenteuses
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Tolterodine
Gravité: Majeure
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolterodine: major interaction.
Dernière mise à jour
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Résumé
Cobicistat inhibits CYP3A4 and CYP2D6, both involved in tolterodine metabolism, raising tolterodine and its active metabolite exposure. This increases anticholinergic adverse effects and potential QT prolongation.
Ce que signifie cette interaction, en termes simples
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cobicistat inhibits CYP3A4 and CYP2D6, reducing tolterodine clearance.
Conduite à tenir
Limit tolterodine to 1 mg twice daily (or lower) and monitor for anticholinergic effects, urinary retention and QT-related symptoms.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Tolterodine
- Clarithromycin + Tolterodine Majeure
- Clozapine + Tolterodine Majeure
- Cobicistat + Tolterodine Majeure
- Dronedarone + Tolterodine Majeure
- Droperidol + Tolterodine Majeure
- Erythromycin base + Tolterodine Majeure
Questions fréquentes
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Tolterodine?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits CYP3A4 and CYP2D6, both involved in tolterodine metabolism, raising tolterodine and its active metabolite exposure. This increases anticholinergic adverse effects and potential QT prolongation.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit tolterodine to 1 mg twice daily (or lower) and monitor for anticholinergic effects, urinary retention and QT-related symptoms.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
