Interactions médicamenteuses
Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Gravité: Contre-indiquée
Ethinyl estradiol-norgestimate and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
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Résumé
Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Ritonavir may also reduce contraceptive hormone exposure.
Ce que signifie cette interaction, en termes simples
Ethinyl estradiol-norgestimate and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
The mechanism of the ALT elevation is not established; ritonavir may also alter estrogen metabolism.
Conduite à tenir
Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contre-indiquée
- Ethinyl estradiol-norgestimate + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-norgestimate Majeure
- Amobarbital + Ethinyl estradiol-norgestimate Majeure
- Anastrozole + Ethinyl estradiol-norgestimate Majeure
- Apalutamide + Ethinyl estradiol-norgestimate Majeure
Questions fréquentes
Can I take Ethinyl estradiol-norgestimate with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-norgestimate and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Ritonavir may also reduce contraceptive hormone exposure.
How serious is the interaction between Ethinyl estradiol-norgestimate and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Tranexamic acid, Aminocaproic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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