Interactions médicamenteuses
Measles mumps rubella and varicella vaccine live + Methotrexate
Gravité: Contre-indiquée
Measles mumps rubella and varicella vaccine live and Methotrexate: contraindicated interaction.
Dernière mise à jour
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Résumé
This combined live vaccine contains four attenuated viruses that may replicate unchecked in patients on methotrexate, risking disseminated infection. Vaccine effectiveness may also be reduced.
Ce que signifie cette interaction, en termes simples
Measles mumps rubella and varicella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Methotrexate-induced immunosuppression impairs clearance of live attenuated viruses.
Conduite à tenir
Do not administer during methotrexate therapy; give at least 4 weeks before starting treatment when possible, or use separate non-live alternatives where available.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Methotrexate
- Acitretin + Methotrexate Contre-indiquée
- Adenovirus types 4 and 7 live + Methotrexate Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contre-indiquée
- Ketorolac + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine live + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine + Methotrexate Contre-indiquée
Questions fréquentes
Can I take Measles mumps rubella and varicella vaccine live with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This combined live vaccine contains four attenuated viruses that may replicate unchecked in patients on methotrexate, risking disseminated infection. Vaccine effectiveness may also be reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during methotrexate therapy; give at least 4 weeks before starting treatment when possible, or use separate non-live alternatives where available.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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