Interactions médicamenteuses
Mercaptopurine + Smallpox vaccine live
Gravité: Contre-indiquée
Mercaptopurine and Smallpox vaccine live: contraindicated interaction.
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Résumé
Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
Ce que signifie cette interaction, en termes simples
Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Immunosuppression from a purine antimetabolite permits uncontrolled replication of vaccinia virus and impairs immune response.
Conduite à tenir
Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contre-indiquée
- Azathioprine + Mercaptopurine Contre-indiquée
- Bcg vaccine live + Mercaptopurine Contre-indiquée
- Febuxostat + Mercaptopurine Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contre-indiquée
- Adalimumab + Mercaptopurine Majeure
Questions fréquentes
Can I take Mercaptopurine with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Mercaptopurine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed people. Mercaptopurine increases this risk and reduces the protective response.
How serious is the interaction between Mercaptopurine and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients on mercaptopurine except in a true exposure emergency under specialist guidance. A non-replicating alternative should be considered where available.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
