Interactions médicamenteuses
Moexipril + Protein a column
Gravité: Contre-indiquée
Moexipril and Protein a column: contraindicated interaction.
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Résumé
Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
Ce que signifie cette interaction, en termes simples
Moexipril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
ACE inhibition blocks kininase II degradation of bradykinin, which is increased by column-mediated contact activation, causing anaphylactoid reactions.
Conduite à tenir
Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Moexipril
- Aliskiren + Moexipril Contre-indiquée
- Moexipril + Sacubitril / valsartan Contre-indiquée
- Moexipril + Sacubitril-valsartan Contre-indiquée
- Amifostine + Moexipril Majeure
- Amiloride + Moexipril Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Moexipril Majeure
Questions fréquentes
Can I take Moexipril with Protein a column?
MediHelp rates the interaction as contraindicated. Moexipril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
How serious is the interaction between Moexipril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Moexipril page.
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