Interactions médicamenteuses
Nevirapine + St john's wort
Gravité: Contre-indiquée
Nevirapine and St john's wort: contraindicated interaction.
Dernière mise à jour
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Résumé
St John's wort can substantially lower nevirapine concentrations, which may lead to virologic failure and resistance. Nevirapine's resistance barrier is low.
Ce que signifie cette interaction, en termes simples
Nevirapine and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
St John's wort induces CYP3A4 and CYP2B6 and P-glycoprotein, increasing nevirapine clearance.
Conduite à tenir
Do not use together. If St John's wort was used, stop it and monitor HIV RNA, noting that enzyme induction fades over about two weeks.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contre-indiquée
- Nevirapine + Ranolazine Contre-indiquée
- Abemaciclib + Nevirapine Majeure
- Acalabrutinib + Nevirapine Majeure
- Amobarbital + Nevirapine Majeure
- Apalutamide + Nevirapine Majeure
Questions fréquentes
Can I take Nevirapine with St john's wort?
MediHelp rates the interaction as contraindicated. Nevirapine and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort can substantially lower nevirapine concentrations, which may lead to virologic failure and resistance. Nevirapine's resistance barrier is low.
How serious is the interaction between Nevirapine and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If St John's wort was used, stop it and monitor HIV RNA, noting that enzyme induction fades over about two weeks.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, Abemaciclib. The full list is on the Nevirapine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
