दवा संदर्भ
Danicopan
Danicopan is a medicine in the class miscellaneous.
- दवा वर्ग: Miscellaneous
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Miscellaneous
- ATC कोड
- L04AJ09
- सामान्य रूप
- टैबलेट
- सामान्य मात्राएँ
- 100 mg
- ज्ञात अंतःक्रियाएँ
- 97 (मध्यम: 68 · हल्की: 29)
- ब्रांड नाम
- 2
- देश और बाज़ार
- 2
यह कैसे काम करती है
Danicopan reversibly binds complement Factor D and selectively inhibits the alternative complement pathway. It prevents cleavage of Factor B and formation of C3 convertase (C3bBb), thereby controlling C3 fragment-mediated extravascular hemolysis in PNH.
वयस्कों की सामान्य खुराक (लेबल सारांश)
Extravascular hemolysis in PNH (add-on to ravulizumab or eculizumab): starting dose 150 mg orally three times a day, with or without food; may increase to 200 mg three times a day
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unknown No human data. Use may be considered after risk-benefit assessment; untreated PNH carries maternal and fetal risks. No adverse developmental effects in rabbits or rats.
- स्तनपान
- Unsafe No human milk data; present in animal milk. Advise not to breastfeed during treatment and for 3 days after the last dose.
रिपोर्ट किए गए दुष्प्रभाव
- Headache
- Vomiting
- Pyrexia
- Increased alanine aminotransferase
- Hypertension
- Pain in extremity
बॉक्स्ड चेतावनियाँ
- Complement inhibitor that increases the risk of serious, life-threatening or fatal infections with encapsulated bacteria (Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type B). Vaccinate against N. meningitidis and S. pneumoniae at least 2 weeks before the first dose unless delaying therapy is riskier, and follow current ACIP recommendations. Risk persists despite vaccination. Monitor for early signs of infection and evaluate immediately. Available only through the VOYDEYA REMS.
प्रतिसंकेत
- Initiation in patients with unresolved serious infection caused by encapsulated bacteria (Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type B)
किन्हें सावधानी रखनी चाहिए
- Serious encapsulated bacterial infections can occur in vaccinated and unvaccinated patients; if urgent therapy is needed in patients not up to date on vaccines, give antibacterial prophylaxis and vaccinate as soon as possible.
- Hepatic enzyme elevations (ALT) occurred; assess liver enzymes before and periodically during treatment.
- After discontinuation, monitor closely for at least 2 weeks for signs of hemolysis; continue background ravulizumab or eculizumab.
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (97)
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
- Colchicine + Danicopan Moderate
- Crizotinib + Danicopan Moderate
- Cyclosporin + Danicopan Moderate
- Dabigatran etexilate + Danicopan Moderate
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Danicopan का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
अक्सर पूछे जाने वाले प्रश्न
What is Danicopan used for?
Danicopan is a medicine in the class miscellaneous.
What side effects have been reported with Danicopan?
Headache, Vomiting, Pyrexia, Increased alanine aminotransferase, Hypertension, Pain in extremity. Serious warning: Complement inhibitor that increases the risk of serious, life-threatening or fatal infections with encapsulated bacteria (Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type B).
Can Danicopan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. Use may be considered after risk-benefit assessment; untreated PNH carries maternal and fetal risks. No adverse developmental effects in rabbits or rats. Breastfeeding: Unsafe. No human milk data; present in animal milk. Advise not to breastfeed during treatment and for 3 days after the last dose.
What does Danicopan interact with?
MediHelp lists 97 known interactions for Danicopan. Moderate: 68 · Minor: 29. The most serious include Amiodarone, Apixaban, Atorvastatin.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
