दवा संदर्भ
Iptacopan
Iptacopan is a medicine in the class miscellaneous. It is used for nephropathy.
- दवा वर्ग: Miscellaneous
- उपयोग: nephropathy
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Miscellaneous
- सामान्य रूप
- कैप्सूल
- सामान्य मात्राएँ
- 200 mg
- ज्ञात अंतःक्रियाएँ
- 5 (मध्यम: 5)
- ब्रांड नाम
- 2
- देश और बाज़ार
- 2
उपयोग
यह कैसे काम करती है
Iptacopan binds Factor B of the alternative complement pathway and regulates C3 cleavage, generation of downstream effectors and amplification of the terminal pathway. In PNH it controls both C3b-mediated extravascular hemolysis and terminal complement-mediated intravascular hemolysis.
वयस्कों की सामान्य खुराक (लेबल सारांश)
PNH, IgAN, C3G: 200 mg orally twice daily, without regard to food; swallow capsules whole
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unknown Human data are insufficient to show a risk; no fetal harm in rats or rabbits at 4 to 6 times human exposure. Untreated PNH or the kidney diseases it treats carry serious risks in pregnancy. US label: use may be considered after weighing risks and benefits.
- स्तनपान
- Unknown No data on milk or infant effects. LactMed repeats the label advice. US label: stop breastfeeding during treatment and for 5 days after the last dose because of possible serious infant reactions (a general precaution; no specific harm is known).
रिपोर्ट किए गए दुष्प्रभाव
- Headache
- Nasopharyngitis
- Diarrhea
- Abdominal pain
- Bacterial infection
- Viral infection
बॉक्स्ड चेतावनियाँ
- Complement inhibitor that increases the risk of serious, life-threatening or fatal infections caused by encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b). Complete or update vaccination at least 2 weeks before the first dose unless delaying therapy is riskier, following ACIP recommendations. Risk persists even with vaccine antibodies. Monitor for early signs of infection and evaluate immediately. Available only through the FABHALTA REMS.
प्रतिसंकेत
- Serious hypersensitivity to iptacopan or any of the excipients.
- Initiation in patients with unresolved serious infection caused by encapsulated bacteria.
किन्हें सावधानी रखनी चाहिए
- Serious infections with encapsulated bacteria; if urgent therapy is needed in patients not up to date on vaccines, give antibacterial prophylaxis and vaccinate as soon as possible.
- Available only through the FABHALTA REMS; prescribers and pharmacies must be certified.
- PNH: after discontinuation, monitor for at least 2 weeks for signs and symptoms of hemolysis.
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (5)
- Carbamazepine + Iptacopan Moderate
- Gemfibrozil + Iptacopan Moderate
- Iptacopan + Phenytoin Moderate
- Iptacopan + Rifampicin Moderate
- Iptacopan + Secobarbital Moderate
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Iptacopan का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
अक्सर पूछे जाने वाले प्रश्न
What is Iptacopan used for?
Iptacopan is a medicine in the class miscellaneous. It is used for Nephropathy.
What side effects have been reported with Iptacopan?
Headache, Nasopharyngitis, Diarrhea, Abdominal pain, Bacterial infection, Viral infection. Serious warning: Complement inhibitor that increases the risk of serious, life-threatening or fatal infections caused by encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b).
Can Iptacopan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Human data are insufficient to show a risk; no fetal harm in rats or rabbits at 4 to 6 times human exposure. Untreated PNH or the kidney diseases it treats carry serious risks in pregnancy. US label: use may be considered after weighing risks and benefits. Breastfeeding: Unknown. No data on milk or infant effects. LactMed repeats the label advice. US label: stop breastfeeding during treatment and for 5 days after the last dose because of possible serious infant reactions (a general precaution; no specific harm is known).
What does Iptacopan interact with?
MediHelp lists 5 known interactions for Iptacopan. Moderate: 5. The most serious include Carbamazepine, Gemfibrozil, Phenytoin.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
