दवा संदर्भ
Lomitapide
Lomitapide is a medicine in the class cardiovascular. It is used for hypercholesterolemia.
- दवा वर्ग: Cardiovascular
- उपयोग: hypercholesterolemia
अंतिम अपडेट स्रोत: US FDA label, EMA SmPC
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Cardiovascular
- ATC कोड
- C10AX12
- सामान्य रूप
- कैप्सूल
- ज्ञात अंतःक्रियाएँ
- 146 (निषिद्ध: 16 · गंभीर: 28 · मध्यम: 68 · हल्की: 34)
- ब्रांड नाम
- 2
- देश और बाज़ार
- 2
उपयोग
यह कैसे काम करती है
Binds and inhibits microsomal triglyceride transfer protein (MTP), preventing assembly of apo B-containing lipoproteins in enterocytes and hepatocytes. This inhibits chylomicron and VLDL synthesis and reduces plasma LDL-C.
वयस्कों की सामान्य खुराक (लेबल सारांश)
HoFH (18 years and older): start 5 mg orally once daily; titrate per Table 1 (weeks 0 to 2 at 5 mg, then 10 mg, 20 mg, 40 mg); maximum 60 mg daily from week 15, based on LDL-C target, safety and tolerability
आमतौर पर कैसे ली जाती है
Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unsafe Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected.
- स्तनपान
- Unsafe No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.
रिपोर्ट किए गए दुष्प्रभाव
- Diarrhea
- Nausea
- Dyspepsia
- Abdominal pain
- Vomiting
- Chest pain
बॉक्स्ड चेतावनियाँ
- Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis. Measure ALT, AST, alkaline phosphatase and bilirubin before starting, then ALT and AST regularly. Adjust dose if ALT or AST ≥3 times ULN and discontinue for clinically significant liver toxicity. Available only through the JUXTAPID REMS Program. Prescribe only for HoFH.
प्रतिसंकेत
- Pregnancy
- Concomitant use with moderate or strong CYP3A4 inhibitors
- Moderate or severe hepatic impairment (Child-Pugh B or C) and active liver disease, including unexplained persistent transaminase elevations
किन्हें सावधानी रखनी चाहिए
- Hepatotoxicity: transaminase elevations and hepatic steatosis; monitor liver tests before each dose increase or monthly in the first year, then at least every 3 months
- Embryo-fetal toxicity: may cause fetal harm; negative pregnancy test before starting and effective contraception during treatment and for two weeks after
- Reduced absorption of fat-soluble vitamins and fatty acids; daily vitamin E and essential fatty acid supplements needed
Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (146)
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
- Erythromycin + Lomitapide Contraindicated
- Fluconazole + Lomitapide Contraindicated
- Imatinib + Lomitapide Contraindicated
- Itraconazole + Lomitapide Contraindicated
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Lomitapide का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
इसी वर्ग की अन्य दवाएँ
अक्सर पूछे जाने वाले प्रश्न
What is Lomitapide used for?
Lomitapide is a medicine in the class cardiovascular. It is used for Hypercholesterolemia.
What side effects have been reported with Lomitapide?
Diarrhea, Nausea, Dyspepsia, Abdominal pain, Vomiting, Chest pain. Serious warning: Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis.
Can Lomitapide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected. Breastfeeding: Unsafe. No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.
What does Lomitapide interact with?
MediHelp lists 146 known interactions for Lomitapide. Contraindicated: 16 · Major: 28 · Moderate: 68 · Minor: 34. The most serious include Aprepitant, Clarithromycin, Crizotinib.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
