दवा संदर्भ
Metreleptin
Metreleptin is a medicine in the class endocrine.
- दवा वर्ग: Endocrine
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Endocrine
- सामान्य रूप
- इंजेक्शन
- सामान्य मात्राएँ
- 11.3 mg/2.2 ml
- ज्ञात अंतःक्रियाएँ
- 23 (गंभीर: 4 · मध्यम: 19)
- ब्रांड नाम
- 2
- देश और बाज़ार
- 2
यह कैसे काम करती है
Leptin analog that binds to and activates the human leptin receptor (ObR), a Class I cytokine receptor that signals through the JAK/STAT pathway, replacing deficient leptin in generalized lipodystrophy.
वयस्कों की सामान्य खुराक (लेबल सारांश)
Generalized lipodystrophy, males greater than 40 kg: start 2.5 mg subcutaneously once daily; adjust by 1.25 mg to 2.5 mg; maximum 10 mg/day
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unknown Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol).
- स्तनपान
- Unknown No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.
रिपोर्ट किए गए दुष्प्रभाव
- Headache
- Hypoglycemia
- Decreased weight
- Abdominal pain
- Arthralgia
- Dizziness
बॉक्स्ड चेतावनियाँ
- Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy. Severe infection and/or worsening metabolic control have been reported. Test for neutralizing antibodies in patients with severe infections or suspected loss of efficacy.
प्रतिसंकेत
- General obesity not associated with congenital leptin deficiency.
- Prior severe hypersensitivity reactions to metreleptin or any product component.
किन्हें सावधानी रखनी चाहिए
- Neutralizing antibodies may inhibit endogenous leptin and cause loss of efficacy; test if severe infections or loss of efficacy occur.
- T-cell lymphoma: consider benefits and risks in patients with acquired generalized lipodystrophy or significant hematologic abnormalities.
- Hypoglycemia with concomitant insulin or insulin secretagogues; monitor blood glucose.
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (23)
- Insulin aspart + Metreleptin Major
- Insulin glargine + Metreleptin Major
- Insulin glargine-lixisenatide + Metreleptin Major
- Insulin lispro + Metreleptin Major
- Chlorpropamide + Metreleptin Moderate
- Cyclosporin + Metreleptin Moderate
- Gliclazide + Metreleptin Moderate
- Glimepiride + Metreleptin Moderate
- Glimepiride-pioglitazone + Metreleptin Moderate
- Glipizide + Metreleptin Moderate
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Metreleptin का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
अक्सर पूछे जाने वाले प्रश्न
What is Metreleptin used for?
Metreleptin is a medicine in the class endocrine.
What side effects have been reported with Metreleptin?
Headache, Hypoglycemia, Decreased weight, Abdominal pain, Arthralgia, Dizziness. Serious warning: Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy.
Can Metreleptin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol). Breastfeeding: Unknown. No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.
What does Metreleptin interact with?
MediHelp lists 23 known interactions for Metreleptin. Major: 4 · Moderate: 19. The most serious include Insulin aspart, Insulin glargine, Insulin glargine-lixisenatide.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
