दवाओं की अंतःक्रिया
Alprazolam + Amobarbital
गंभीरता: गंभीर
Alprazolam and Amobarbital: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Barbiturates and benzodiazepines together produce additive sedation and can cause profound respiratory depression. In addition, amobarbital induces CYP3A4 and can lower alprazolam concentrations, weakening its anxiolytic effect and complicating dose adjustments.
इस इंटरैक्शन का सरल भाषा में अर्थ
Alprazolam and Amobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Amobarbital belongs to Central Nervous System.
ऐसा क्यों होता है
Additive GABA-A mediated CNS depression plus CYP3A4 induction by amobarbital increasing alprazolam clearance.
क्या करें
Avoid combining where possible; if needed, monitor respiratory status and level of consciousness and adjust alprazolam dose to clinical response. Re-evaluate doses if the barbiturate is stopped, as induction wanes.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Alprazolam और Amobarbital की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Alprazolam के अन्य इंटरैक्शन
Amobarbital के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Alprazolam with Amobarbital?
MediHelp rates the interaction as major. Alprazolam and Amobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce additive sedation and can cause profound respiratory depression. In addition, amobarbital induces CYP3A4 and can lower alprazolam concentrations, weakening its anxiolytic effect and complicating dose adjustments.
How serious is the interaction between Alprazolam and Amobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, monitor respiratory status and level of consciousness and adjust alprazolam dose to clinical response. Re-evaluate doses if the barbiturate is stopped, as induction wanes.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
