दवाओं की अंतःक्रिया
Amlodipine-hydrochlorothiazide-valsartan + Diflunisal
गंभीरता: गंभीर
Amlodipine-hydrochlorothiazide-valsartan and Diflunisal: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Diflunisal, an NSAID, can blunt the blood pressure-lowering effect of valsartan and hydrochlorothiazide. Together with the ARB and diuretic it raises the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amlodipine-hydrochlorothiazide-valsartan and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
ऐसा क्यों होता है
Prostaglandin synthesis inhibition causes sodium retention and reduced renal perfusion, compounding the renal effects of ARB and diuretic therapy.
क्या करें
Avoid combined use when possible and choose paracetamol for analgesia. If an NSAID is needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amlodipine-hydrochlorothiazide-valsartan और Diflunisal की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-hydrochlorothiazide-valsartan के अन्य इंटरैक्शन
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan निषिद्ध
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan गंभीर
Diflunisal के अन्य इंटरैक्शन
- Diflunisal + Ketorolac निषिद्ध
- Diflunisal + Ketorolac intranasal निषिद्ध
- Acemetacin + Diflunisal गंभीर
- Acetazolamide + Diflunisal गंभीर
- Alteplase + Diflunisal गंभीर
- Amiloride + Diflunisal गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Amlodipine-hydrochlorothiazide-valsartan with Diflunisal?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Diflunisal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diflunisal, an NSAID, can blunt the blood pressure-lowering effect of valsartan and hydrochlorothiazide. Together with the ARB and diuretic it raises the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diflunisal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use when possible and choose paracetamol for analgesia. If an NSAID is needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
