दवाओं की अंतःक्रिया
Amlodipine-hydrochlorothiazide-valsartan + Lithium
गंभीरता: गंभीर
Amlodipine-hydrochlorothiazide-valsartan and Lithium: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Both valsartan and hydrochlorothiazide can reduce renal lithium clearance, raising serum lithium and risking toxicity such as tremor, ataxia, confusion and arrhythmias. The thiazide effect is particularly well documented and the risk is greater with volume depletion.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amlodipine-hydrochlorothiazide-valsartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lithium belongs to Central Nervous System.
ऐसा क्यों होता है
Reduced renal lithium excretion due to increased proximal tubular sodium and lithium reabsorption from thiazide-induced volume contraction and angiotensin receptor blockade.
क्या करें
Avoid if possible; otherwise check lithium level within the first week after starting and after dose changes and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and maintain hydration.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amlodipine-hydrochlorothiazide-valsartan और Lithium की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-hydrochlorothiazide-valsartan के अन्य इंटरैक्शन
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan निषिद्ध
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan गंभीर
Lithium के अन्य इंटरैक्शन
- Lithium + Thioridazine निषिद्ध
- Lithium + Vandetanib निषिद्ध
- Aceclofenac + Lithium गंभीर
- Acemetacin + Lithium गंभीर
- Amisulpride + Lithium गंभीर
- Amlodipine-benazepril + Lithium गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lithium?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both valsartan and hydrochlorothiazide can reduce renal lithium clearance, raising serum lithium and risking toxicity such as tremor, ataxia, confusion and arrhythmias. The thiazide effect is particularly well documented and the risk is greater with volume depletion.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise check lithium level within the first week after starting and after dose changes and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and maintain hydration.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
