दवाओं की अंतःक्रिया
Aprepitant + Atogepant
गंभीरता: मध्यम
Aprepitant and Atogepant: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
इस इंटरैक्शन का सरल भाषा में अर्थ
Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Atogepant belongs to Central Nervous System.
ऐसा क्यों होता है
Aprepitant inhibits CYP3A4, reducing atogepant metabolism, although aprepitant can also induce CYP3A4 with longer exposure.
क्या करें
Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Aprepitant और Atogepant की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Aprepitant के अन्य इंटरैक्शन
- Aprepitant + Lomitapide निषिद्ध
- Aprepitant + Pimozide निषिद्ध
- Aprepitant + Avapritinib गंभीर
- Aprepitant + Bosutinib गंभीर
- Aprepitant + Carbamazepine गंभीर
- Aprepitant + Cobicistat गंभीर
Atogepant के अन्य इंटरैक्शन
- Amobarbital + Atogepant मध्यम
- Apalutamide + Atogepant मध्यम
- Armodafinil + Atogepant मध्यम
- Atogepant + Bosentan मध्यम
- Atogepant + Carbamazepine मध्यम
- Atogepant + Chloramphenicol मध्यम
अक्सर पूछे जाने वाले प्रश्न
Can I take Aprepitant with Atogepant?
MediHelp rates the interaction as moderate. Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Aprepitant and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
