दवाओं की अंतःक्रिया
Aripiprazole + Mitotane
गंभीरता: गंभीर
Aripiprazole and Mitotane: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.
इस इंटरैक्शन का सरल भाषा में अर्थ
Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Mitotane belongs to Oncology.
ऐसा क्यों होता है
Induction of CYP3A4 increases aripiprazole clearance.
क्या करें
Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Aripiprazole और Mitotane की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Aripiprazole के अन्य इंटरैक्शन
Mitotane के अन्य इंटरैक्शन
- Doravirine + Mitotane निषिद्ध
- Fostemsavir + Mitotane निषिद्ध
- Lorlatinib + Mitotane निषिद्ध
- Abiraterone + Mitotane गंभीर
- Apixaban + Mitotane गंभीर
- Aprepitant + Mitotane गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Aripiprazole with Mitotane?
MediHelp rates the interaction as major. Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Aripiprazole and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
