दवाओं की अंतःक्रिया
Artemether / lumefantrine + Bosentan
गंभीरता: गंभीर
Artemether / lumefantrine and Bosentan: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
इस इंटरैक्शन का सरल भाषा में अर्थ
Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
CYP3A4 induction by bosentan increases the metabolism of artemether and lumefantrine.
क्या करें
Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Artemether / lumefantrine और Bosentan की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Bosentan के अन्य इंटरैक्शन
- Bosentan + Cyclosporin निषिद्ध
- Bosentan + Cyclosporine निषिद्ध
- Bosentan + Glyburide निषिद्ध
- Bosentan + Glyburide-metformin निषिद्ध
- Bosentan + Lonafarnib निषिद्ध
- Bosentan + Sparsentan निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Artemether / lumefantrine with Bosentan?
MediHelp rates the interaction as major. Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
How serious is the interaction between Artemether / lumefantrine and Bosentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
