Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid

MediHelp rates the interaction as moderate. Benzathine penicillin g and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that colonic bacteria convert to its active laxative form. Antibiotics that disrupt the colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Parenteral penicillin G has limited colonic exposure, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid scheduling the antibiotic course around the bowel preparation. Assess the quality of bowel cleansing and consider additional preparation if cleansing is inadequate.

MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.