दवाओं की अंतःक्रिया
Cabotegravir + Phenytoin
गंभीरता: निषिद्ध
Cabotegravir and Phenytoin: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Phenytoin substantially reduces cabotegravir concentrations, which may cause loss of virologic response and integrase inhibitor resistance. This applies to oral and long-acting injectable forms.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cabotegravir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabotegravir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
ऐसा क्यों होता है
Phenytoin induces UGT1A1 and UGT1A9, the main enzymes eliminating cabotegravir.
क्या करें
Do not co-administer; select a non-inducing anticonvulsant. Inducer effects can persist for weeks after phenytoin is stopped, so delay cabotegravir accordingly.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cabotegravir और Phenytoin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Phenytoin के अन्य इंटरैक्शन
Cabotegravir के अन्य इंटरैक्शन
- Apalutamide + Cabotegravir निषिद्ध
- Cabotegravir + Carbamazepine निषिद्ध
- Cabotegravir + Oxcarbazepine निषिद्ध
- Cabotegravir + Phenobarbitone निषिद्ध
- Cabotegravir + Rifabutin निषिद्ध
- Cabotegravir + Rifampicin निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Cabotegravir with Phenytoin?
MediHelp rates the interaction as contraindicated. Cabotegravir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin substantially reduces cabotegravir concentrations, which may cause loss of virologic response and integrase inhibitor resistance. This applies to oral and long-acting injectable forms.
How serious is the interaction between Cabotegravir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select a non-inducing anticonvulsant. Inducer effects can persist for weeks after phenytoin is stopped, so delay cabotegravir accordingly.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Doravirine. The full list is on the Phenytoin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
