दवाओं की अंतःक्रिया
Carbamazepine + Sofosbuvir-velpatasvir
गंभीरता: गंभीर
Carbamazepine and Sofosbuvir-velpatasvir: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Carbamazepine is a potent inducer of P-glycoprotein and of several CYP enzymes, and it can substantially lower plasma concentrations of sofosbuvir and velpatasvir. This may lead to loss of antiviral activity and treatment failure or resistance. The combination is not recommended in labeling.
इस इंटरैक्शन का सरल भाषा में अर्थ
Carbamazepine and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Sofosbuvir-velpatasvir belongs to Anti Virals.
ऐसा क्यों होता है
Carbamazepine induces P-gp and CYP2B6, CYP2C8 and CYP3A4, increasing clearance and reducing absorption of sofosbuvir and velpatasvir.
क्या करें
Avoid the combination and switch to an anticonvulsant without enzyme-inducing activity, such as levetiracetam, if clinically possible. If it cannot be avoided, consult a hepatology or infectious disease specialist and confirm sustained virologic response.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Carbamazepine और Sofosbuvir-velpatasvir की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Sofosbuvir-velpatasvir के अन्य इंटरैक्शन
Carbamazepine के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Carbamazepine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as major. Carbamazepine and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a potent inducer of P-glycoprotein and of several CYP enzymes, and it can substantially lower plasma concentrations of sofosbuvir and velpatasvir. This may lead to loss of antiviral activity and treatment failure or resistance. The combination is not recommended in labeling.
How serious is the interaction between Carbamazepine and Sofosbuvir-velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to an anticonvulsant without enzyme-inducing activity, such as levetiracetam, if clinically possible. If it cannot be avoided, consult a hepatology or infectious disease specialist and confirm sustained virologic response.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
