दवाओं की अंतःक्रिया
Carbidopa-entacapone-levodopa + Isocarboxazid
गंभीरता: निषिद्ध
Carbidopa-entacapone-levodopa and Isocarboxazid: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
इस इंटरैक्शन का सरल भाषा में अर्थ
Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
ऐसा क्यों होता है
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
क्या करें
Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Carbidopa-entacapone-levodopa और Isocarboxazid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Carbidopa-entacapone-levodopa के अन्य इंटरैक्शन
- Carbidopa-entacapone-levodopa + Phenelzine निषिद्ध
- Carbidopa-entacapone-levodopa + Selegiline transdermal निषिद्ध
- Carbidopa-entacapone-levodopa + Tranylcypromine निषिद्ध
- Amisulpride + Carbidopa-entacapone-levodopa गंभीर
- Asenapine transdermal + Carbidopa-entacapone-levodopa गंभीर
- Carbidopa-entacapone-levodopa + Chlorpromazine गंभीर
Isocarboxazid के अन्य इंटरैक्शन
- 5-HTP + Isocarboxazid निषिद्ध
- Amitriptyline + Isocarboxazid निषिद्ध
- Amobarbital + Isocarboxazid निषिद्ध
- Amoxapine + Isocarboxazid निषिद्ध
- Apraclonidine + Isocarboxazid निषिद्ध
- Atomoxetine + Isocarboxazid निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Carbidopa-entacapone-levodopa with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Phenelzine, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-entacapone-levodopa page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
