दवाओं की अंतःक्रिया
Celecoxib + Pemetrexed
गंभीरता: गंभीर
Celecoxib and Pemetrexed: major interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
NSAIDs can reduce renal clearance of pemetrexed, raising its exposure and the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment. Celecoxib has a relatively long half-life, so the effect can persist.
इस इंटरैक्शन का सरल भाषा में अर्थ
Celecoxib and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
ऐसा क्यों होता है
NSAID-induced reduction in renal prostaglandin-dependent perfusion and glomerular filtration decreases renal elimination of pemetrexed.
क्या करें
Where possible, hold celecoxib in the days before, on the day of and after pemetrexed, following the labeling schedule for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Celecoxib और Pemetrexed की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Celecoxib के अन्य इंटरैक्शन
- Celecoxib + Ketorolac निषिद्ध
- Celecoxib + Ketorolac intranasal निषिद्ध
- Aceclofenac + Celecoxib गंभीर
- Acemetacin + Celecoxib गंभीर
- Amiloride + Celecoxib गंभीर
- Apixaban + Celecoxib गंभीर
Pemetrexed के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Celecoxib with Pemetrexed?
MediHelp rates the interaction as major. Celecoxib and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce renal clearance of pemetrexed, raising its exposure and the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment. Celecoxib has a relatively long half-life, so the effect can persist.
How serious is the interaction between Celecoxib and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, hold celecoxib in the days before, on the day of and after pemetrexed, following the labeling schedule for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
