दवाओं की अंतःक्रिया
Cephaloridine + Tobramycin
गंभीरता: गंभीर
Cephaloridine and Tobramycin: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Additive proximal tubular toxicity, with reduced renal clearance of tobramycin raising its exposure.
क्या करें
Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cephaloridine और Tobramycin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Tobramycin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cephaloridine with Tobramycin?
MediHelp rates the interaction as major. Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
How serious is the interaction between Cephaloridine and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
