दवाओं की अंतःक्रिया
Chlorthalidone + Digoxin
गंभीरता: गंभीर
Chlorthalidone and Digoxin: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Hypokalemia and hypomagnesemia induced by chlorthalidone sensitize the myocardium to digoxin and increase the risk of digoxin toxicity and arrhythmias. The risk is greater in elderly patients and those with renal impairment.
इस इंटरैक्शन का सरल भाषा में अर्थ
Chlorthalidone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorthalidone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
ऐसा क्यों होता है
Diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its proarrhythmic effects.
क्या करें
Monitor serum potassium and magnesium regularly and keep potassium in the normal range. Check digoxin level and ECG if symptoms of toxicity occur.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Chlorthalidone और Digoxin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Chlorthalidone के अन्य इंटरैक्शन
Digoxin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Chlorthalidone with Digoxin?
MediHelp rates the interaction as major. Chlorthalidone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hypokalemia and hypomagnesemia induced by chlorthalidone sensitize the myocardium to digoxin and increase the risk of digoxin toxicity and arrhythmias. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Chlorthalidone and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and keep potassium in the normal range. Check digoxin level and ECG if symptoms of toxicity occur.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
