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दवाओं की अंतःक्रिया

Cholic acid + Ketoconazole

गंभीरता: गंभीर

Cholic acid and Ketoconazole: major interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

Ketoconazole may inhibit the bile salt export pump, which cholic acid therapy depends on for hepatic bile salt excretion. Accumulation of conjugated bile salts in hepatocytes can cause liver injury.

इस इंटरैक्शन का सरल भाषा में अर्थ

Cholic acid and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cholic acid belongs to Gastrointestinal Tract; Ketoconazole belongs to Anti Fungals.

साक्ष्य स्तर: Moderate

ऐसा क्यों होता है

Inhibition of the bile salt efflux pump (BSEP) reduces hepatic bile salt elimination.

क्या करें

Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

फार्मासिस्ट से क्या पूछें

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Cholic acid और Ketoconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Cholic acid with Ketoconazole?

MediHelp rates the interaction as major. Cholic acid and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole may inhibit the bile salt export pump, which cholic acid therapy depends on for hepatic bile salt excretion. Accumulation of conjugated bile salts in hepatocytes can cause liver injury.

How serious is the interaction between Cholic acid and Ketoconazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

What other medicines interact with Ketoconazole?

MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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