दवाओं की अंतःक्रिया
Clozapine + Glycopyrrolate
गंभीरता: मध्यम
Clozapine and Glycopyrrolate: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Clozapine has substantial anticholinergic activity, and glycopyrrolate adds peripheral anticholinergic effects. The combination can worsen constipation, potentially leading to ileus or bowel obstruction, and can cause urinary retention, dry mouth and tachycardia.
इस इंटरैक्शन का सरल भाषा में अर्थ
Clozapine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
ऐसा क्यों होता है
Additive antimuscarinic effects on gastrointestinal and other smooth muscle and glandular tissue.
क्या करें
Monitor bowel function and urinary symptoms and use a bowel regimen as needed. Use the lowest effective glycopyrrolate dose and stop it if signs of obstruction develop.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Clozapine और Glycopyrrolate की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Clozapine के अन्य इंटरैक्शन
- Clozapine + Deferiprone निषिद्ध
- Clozapine + Irinotecan निषिद्ध
- Clozapine + Pimozide निषिद्ध
- Clozapine + Thioridazine निषिद्ध
- Acalabrutinib + Clozapine गंभीर
- Adagrasib + Clozapine गंभीर
Glycopyrrolate के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Clozapine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Clozapine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has substantial anticholinergic activity, and glycopyrrolate adds peripheral anticholinergic effects. The combination can worsen constipation, potentially leading to ileus or bowel obstruction, and can cause urinary retention, dry mouth and tachycardia.
How serious is the interaction between Clozapine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms and use a bowel regimen as needed. Use the lowest effective glycopyrrolate dose and stop it if signs of obstruction develop.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
