दवाओं की अंतःक्रिया
Cobicistat + Vincristine
गंभीरता: गंभीर
Cobicistat and Vincristine: major interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, which can raise vincristine exposure. This increases the risk of neurotoxicity (peripheral neuropathy, constipation, ileus, seizures) and hematologic toxicity. Serious toxicity has been reported with boosted antiretrovirals and vincristine.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cobicistat and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Vincristine belongs to Oncology.
ऐसा क्यों होता है
Cobicistat inhibits CYP3A4 and P-glycoprotein, reducing vincristine metabolism and efflux.
क्या करें
Avoid the combination where possible and use an antiretroviral regimen without a booster or CYP3A/P-gp inhibitor during vincristine therapy. If unavoidable, monitor closely for neurotoxicity, constipation and myelosuppression and consider dose reduction.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cobicistat और Vincristine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Vincristine के अन्य इंटरैक्शन
Cobicistat के अन्य इंटरैक्शन
- Alfuzosin + Cobicistat निषिद्ध
- Apalutamide + Cobicistat निषिद्ध
- Cobicistat + Colchicine निषिद्ध
- Cobicistat + Dronedarone निषिद्ध
- Cobicistat + Eletriptan निषिद्ध
- Cobicistat + Eplerenone निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Cobicistat with Vincristine?
MediHelp rates the interaction as major. Cobicistat and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, which can raise vincristine exposure. This increases the risk of neurotoxicity (peripheral neuropathy, constipation, ileus, seizures) and hematologic toxicity. Serious toxicity has been reported with boosted antiretrovirals and vincristine.
How serious is the interaction between Cobicistat and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an antiretroviral regimen without a booster or CYP3A/P-gp inhibitor during vincristine therapy. If unavoidable, monitor closely for neurotoxicity, constipation and myelosuppression and consider dose reduction.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
