दवाओं की अंतःक्रिया
Dalfampridine + Glyburide-metformin
गंभीरता: मध्यम
Dalfampridine and Glyburide-metformin: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Both metformin and dalfampridine are eliminated through renal tubular secretion by OCT2. Competition could raise exposure of either drug, and higher dalfampridine levels increase seizure risk, particularly in renal impairment.
इस इंटरैक्शन का सरल भाषा में अर्थ
Dalfampridine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
ऐसा क्यों होता है
Competition for renal tubular secretion via OCT2 may reduce clearance of both drugs.
क्या करें
Check renal function before and during combined use. Watch for seizures or neurologic effects and for metformin adverse effects such as gastrointestinal symptoms.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Dalfampridine और Glyburide-metformin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Glyburide-metformin के अन्य इंटरैक्शन
Dalfampridine के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Dalfampridine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Dalfampridine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are eliminated through renal tubular secretion by OCT2. Competition could raise exposure of either drug, and higher dalfampridine levels increase seizure risk, particularly in renal impairment.
How serious is the interaction between Dalfampridine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined use. Watch for seizures or neurologic effects and for metformin adverse effects such as gastrointestinal symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
