दवाओं की अंतःक्रिया
Desipramine + Isocarboxazid
गंभीरता: निषिद्ध
Desipramine and Isocarboxazid: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
इस इंटरैक्शन का सरल भाषा में अर्थ
Desipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
ऐसा क्यों होता है
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
क्या करें
Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desipramine, and at least 14 days after stopping desipramine before starting the isocarboxazid.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Desipramine और Isocarboxazid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Desipramine के अन्य इंटरैक्शन
- Desipramine + Disopyramide निषिद्ध
- Desipramine + Dofetilide निषिद्ध
- Desipramine + Ibutilide निषिद्ध
- Desipramine + Methylene blue निषिद्ध
- Desipramine + Pentamidine निषिद्ध
- Desipramine + Phenelzine निषिद्ध
Isocarboxazid के अन्य इंटरैक्शन
- 5-HTP + Isocarboxazid निषिद्ध
- Amitriptyline + Isocarboxazid निषिद्ध
- Amobarbital + Isocarboxazid निषिद्ध
- Amoxapine + Isocarboxazid निषिद्ध
- Apraclonidine + Isocarboxazid निषिद्ध
- Atomoxetine + Isocarboxazid निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Desipramine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Desipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desipramine, and at least 14 days after stopping desipramine before starting the isocarboxazid.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
