दवाओं की अंतःक्रिया
Diatrizoate + Glipizide-metformin
गंभीरता: गंभीर
Diatrizoate and Glipizide-metformin: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
इस इंटरैक्शन का सरल भाषा में अर्थ
Diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Contrast-associated acute kidney injury reduces renal elimination of metformin, leading to accumulation and lactic acidosis.
क्या करें
Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Diatrizoate और Glipizide-metformin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Glipizide-metformin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Diatrizoate with Glipizide-metformin?
MediHelp rates the interaction as major. Diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
How serious is the interaction between Diatrizoate and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diazoxide. The full list is on the Glipizide-metformin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
