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दवाओं की अंतःक्रिया

Dihydroergotamine + Isoniazid

गंभीरता: गंभीर

Dihydroergotamine and Isoniazid: major interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

Dihydroergotamine levels rise when CYP3A4 is inhibited, risking ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than agents named in the labeling contraindication, but the toxicity is serious.

इस इंटरैक्शन का सरल भाषा में अर्थ

Dihydroergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dihydroergotamine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.

साक्ष्य स्तर: Low

ऐसा क्यों होता है

Inhibition of CYP3A4 metabolism of dihydroergotamine.

क्या करें

Avoid if possible and choose an alternative migraine therapy during isoniazid treatment. If used, monitor for numbness, coldness, or pain in the extremities and stop at the first signs of ischemia.

फार्मासिस्ट से क्या पूछें

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Dihydroergotamine और Isoniazid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Dihydroergotamine with Isoniazid?

MediHelp rates the interaction as major. Dihydroergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine levels rise when CYP3A4 is inhibited, risking ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than agents named in the labeling contraindication, but the toxicity is serious.

How serious is the interaction between Dihydroergotamine and Isoniazid?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative migraine therapy during isoniazid treatment. If used, monitor for numbness, coldness, or pain in the extremities and stop at the first signs of ischemia.

What other medicines interact with Isoniazid?

MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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